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Biopharmaceutics And Pharmacokinetics By Venkateswarlu Pdf Download ((FREE))

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Biopharmaceutics And Pharmacokinetics By Venkateswarlu Pdf Download

development of unidirectional release buccoadhesive tablets involves preparation of core tablets and coating of the core tablets with water impermeable polymer (). badam gum: a natural polymer in mucoadhesive drug delivery. design, optimization, and biopharmaceutical evaluation of badam gum-based metoprolol succinate buccoadhesive tabletsall authors chaithanya krishna mylangam, sudhakar beeravelli, jyothi medikonda, jagannadha subrahmanyam pidaparthi & venkata ramana murthy kolapalli published online:14 may 2014table 1. formulation of bg-based buccoadhesive tablets of metoprolol succinate. download csv display table

olmesartan medoxomil (om), an ester prodrug of olmesartan, is an angiotensin ii type 1 (at1) receptor antagonist, and is used in the treatment of hypertension [ 1 ]. the major drawback in the therapeutic application and efficacy of om as an oral dosage form is its very low aqueous solubility. the unabsorbed drug leads to gastrointestinal side effects such as abdominal pain, dyspepsia, gastroenteritis and nausea. based on its solubility in physiologically relevant ph conditions and absorption characteristics, om is classified in the biopharmaceutics classification system (bcs) as a class ii drug. improvement in oral bioavailability of om is possible by incorporating into the slns [ 2 ]. slns increase clinical efficacy, reduce the oral dose required to achieve the same effect, and hence reduce the side effects.

metoprolol succinate buccoadhesive tablets were evaluated both for their tableting properties like hardness, friability, thickness, uniformity of weight, and drug content uniformity, in vitro dissolution and mucoadhesive properties like buccoadhesion strength, ex vivo residence time, swelling, and surface ph study. hardness of all the formulations was found to be in the range of 35kg/cm². the thickness of the tablets was measured using vernier callipers and was found to be 2.50.2mm. friability, uniformity of weight, and drug content uniformity were within the limits as per the indian pharmacopoeia (ip). results of the corresponding studies are shown in . badam gum: a natural polymer in mucoadhesive drug delivery. design, optimization, and biopharmaceutical evaluation of badam gum-based metoprolol succinate buccoadhesive tabletsall authors chaithanya krishna mylangam, sudhakar beeravelli, jyothi medikonda, jagannadha subrahmanyam pidaparthi & venkata ramana murthy kolapalli published online:14 may 2014table 2. tableting characteristics of metoprolol succinate buccoadhesive tablets. download csv display table

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