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Category:FIFA (video game series)Survey on ACTH-mediated autoimmune disease of the thyroid.
Autoimmune thyroid disease (AITD) is a common, autoimmune disease, with a significant impact on patient and healthcare quality of life. Despite this, there is no standardized algorithm to assess the disease severity and response to therapy. We aimed to survey all thyroid laboratories for their practice in using the immunoassay for ACTH-mediated AITD. Laboratory thyroid tests were obtained for nine thyroid autoantibodies from six thyroid immunostains at five institutions in the United States, and a series of seven variables were compared among different laboratories, and within the same laboratory between different assays. The coefficient of variation (CV) for each assay was calculated, and the mean CV between different assays was compared to the mean CVs within the same assay. Of the six separate immunoassays performed at five separate institutions, the mean CV for TSH was within the range of 2.4-5.0% (mean 3.3%), for FT4 was within the range of 3.3-7.0% (mean 4.8%), for FT3 was within the range of 3.2-6.4% (mean 4.8%), and for ACTH was within the range of 2.5-6.2% (mean 4.1%). Of the seven variables in the thyroid immunoassay panel, three variables exhibited CV within range (< or =5%) for all laboratories, six variables had CVs within range (< or =10%) for all laboratories, and the mean CV between different assays did not differ significantly from the mean CV within the same assay. The majority of laboratories used a commercial test in the market. We found that the majority of laboratories perform their immunoassays within acceptable ranges; however, some laboratories did not comply with the recommended range. Also, the CVs of some laboratory assays were not meaningfully different from the CVs of other assays within the same laboratory. This information is intended to assist clinicians and laboratories in assessing

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